MOLECULAR AND CLINICAL CHARACTERIZATION OF ROTAVIRUS FROM DIARRHEAL INFANTS ADMITTED TO PEDIATRIC EMERGENY UNITS IN FRANCE, 2006-2010.
ESPID Education. de ROUGEMONT A. Jun 7, 2011; 7683 Disclosure(s): This study was supported by Sanofi-Pasteur-MSD (Lyon, France), the European Rotavirus Network (EuroRotaNet), the University Hospital of Dijon and the National Reference Center for enteric viruses.
Dr. Alexis de ROUGEMONT
Dr. Alexis de ROUGEMONT

This content is available to ESPID members only


Click here for more information or if you are considering becoming an ESPID member.

Abstract
Discussion Forum (0)
Rate & Comment (0)
Background and aims: Rotaviruses are the major cause of acute gastroenteritis in young children worldwide, and require careful surveillance, especially in the context of vaccination programs (current vaccination coverage is under 10% in France). Prospective surveillance is required to monitor and characterize rotavirus infections, including viral and clinical data, and to detect the emergence of potentially epidemic strains.

Methods: Between 2006 and 2010, stool samples and clinical records were collected form 2727 children under 5 years old with acute diarrhea admitted to the pediatric emergency units of 15 French large public hospitals. Rotaviruses were detected, then genotyped by RT-PCR for P (VP4) and G (PV7) types.

Results: The genotyping of 2630 rotaviruses showed that G1 strains (62.9%) were predominant, G9 (23.0%) were decreasing, G2 (9.1%) were very changing, and G3 (4.1%) and G4 (2.5%) circulated locally. Most strains were associated with P[8] (91.2%). Overall, 63 uncommon strains or possible zoonotic reassortants were detected including G12 and G8 rotaviruses, some being closely related to bovine strains. No difference in clinical presentation and severity was found among genotypes.

Conclusions: In spite of the fluctuation of G2 strains, the relative stability of rotavirus genotypes detected in France may ensure vaccine effectiveness in the short and medium terms. Moreover, the likely emergence of G12 and G8 strains should be monitored during ongoing and future vaccination programs, especially as all genotypes can cause severe infections. Special attention should be paid to the emergence of new rotavirus reassortants not included in current rotavirus vaccines.
Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.



Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.


Save Settings