VERY SEVERE CASES OF ROTAVIRUS DISEASE IN GERMANY - A PROSPECTIVE EPIDEMIOLOGICAL SURVEY
ESPID Education. Shai S. 06/07/11; 7700 Disclosure(s): The ESPED fees were covered by GlaxoSmithKline
Sonu Shai
Sonu Shai

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Abstract
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Background
According to the German Infection Protection Act, all cases of rotavirus (RV) diseas in Germany are to be reported to the authorities. There are no data concerning the severity of the disease. Aim of study was to prospectively determine the incidence and the outcome in ver severe cases of RV disease.

Methods
Cases of very severe RV diesease were queried through the collection unit for rare paediatric diseases in Germany (ESPED) using anonymous questionnaires. Data acquisition begean in April 2009 for a planned period of two years.
Inclusion criteria were detection of RV in faeces, patient age 0 - 16 years and one or more of the following criteria: intensive care treatment, hyper- or hyponatremia (>155 mmol/ or <125 mmol/l), clinical signs of encephalopathy (somnolence, seizures, apnoas), deathe due to complications related to RV disease.

Results
96 cases were reported, 96 are evaluable. 17/96 cases were nosocomially acquired, 13/17 were in neonatal intensive care.

79/96 cases were community acquired, their mean age was 16,5 months (0 - 168 months), mean
hospital stay was 10 days (1 - 85 days). 46/79 patients needed intensive care treatment, 55/96
children had signs of encephalopathy, 33/79 cases had a hyper- or hyponatremia. Two death
were reported (a child with syndromal disease with multiple organ anomalies and a child due to hypovolemic shock).

Conclusions
This study shows that RV infections may take a life-threatening course. A substantial number of these cases were nosocomially acquired.
Background
According to the German Infection Protection Act, all cases of rotavirus (RV) diseas in Germany are to be reported to the authorities. There are no data concerning the severity of the disease. Aim of study was to prospectively determine the incidence and the outcome in ver severe cases of RV disease.

Methods
Cases of very severe RV diesease were queried through the collection unit for rare paediatric diseases in Germany (ESPED) using anonymous questionnaires. Data acquisition begean in April 2009 for a planned period of two years.
Inclusion criteria were detection of RV in faeces, patient age 0 - 16 years and one or more of the following criteria: intensive care treatment, hyper- or hyponatremia (>155 mmol/ or <125 mmol/l), clinical signs of encephalopathy (somnolence, seizures, apnoas), deathe due to complications related to RV disease.

Results
96 cases were reported, 96 are evaluable. 17/96 cases were nosocomially acquired, 13/17 were in neonatal intensive care.

79/96 cases were community acquired, their mean age was 16,5 months (0 - 168 months), mean
hospital stay was 10 days (1 - 85 days). 46/79 patients needed intensive care treatment, 55/96
children had signs of encephalopathy, 33/79 cases had a hyper- or hyponatremia. Two death
were reported (a child with syndromal disease with multiple organ anomalies and a child due to hypovolemic shock).

Conclusions
This study shows that RV infections may take a life-threatening course. A substantial number of these cases were nosocomially acquired.
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