ESPID Education. Lebon A. Jun 7, 2011; 7707
Dr. Ankie Lebon
Dr. Ankie Lebon

This content is available to ESPID members only

Click here for more information or if you are considering becoming an ESPID member.

Discussion Forum (0)
Rate & Comment (0)

The currently available pneumococcal vaccines do not protect against all serotypes of Streptococcus pneumoniae. A shift towards non-vaccine serotypes causing colonization and invasive disease has occurred and studies on protein-based vaccines are undertaken. We assessed the association between specific antibodies against pneumococcal virulence proteins and colonization and respiratory tract infections (RTI). Additionally, we assessed to what extend colonization induces a humoral immune response.

Material and Methods
Nasopharyngeal swabs were cultured for pneumococcus at 1.5, 6, 14 and 24 months of age. Serum samples were obtained at birth, 6, 14 and 24 months (n=57 children providing 177 serum samples). Data were collected prior to the pneumococcal vaccine-era. IgG, IgA and IgM levels against seventeen pneumococcal protein vaccine candidates were measured using a bead based flow cytometry technique (xMAP®, Luminex Corporation). Information regarding RTI was questionnaire-derived.

IgG levels to all proteins were high in cord blood, decreased in the first 6 months and increased again thereafter, contrary to the course of IgA and IgM levels. Specific antibodies were induced upon colonization. Increased levels of IgG against BVH-3, NanA and SP1003 at 6 months, NanA, PpmA, PsaA, SlrA, SP0189 and SP1003 at 14 months and SlrA at 24 months were associated with a decreased number of RTI in the 3rd year of life but not with colonization. Maternal anti-pneumococcal antibodies did not protect against pneumococcal colonization and infection.

Certain antibodies against pneumococcal virulence proteins, some of which are induced by colonization, are associated with a decreased number of RTIs in children. This should be taken into account for future pneumococcal vaccine studies.
Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.

Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.

Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.

Save Settings