PANDEMIC A/H1N1V INFLUENZA 2009 IN CHILDREN: A MULTICENTRIC BELGIAN SURVEY
ESPID Education. Blumental s. Jun 7, 2011; 7731
sophie Blumental
sophie Blumental

This content is available to ESPID members only


Click here for more information or if you are considering becoming an ESPID member.

Abstract
Discussion Forum (0)
Rate & Comment (0)
Background and objectives: During the 2009 influenza A/H1N1v pandemic, children were identified as a particular “at risk” group. We conducted a multicentric trial to describe pattern of A/H1N1v infection among hospitalized children.
Material and methods: From 01/07/09 to 31/01/10, we prospectively collected all proven (positive H1N1v PCR) and probable (positive Influenza A antigen or culture) pediatric cases of H1N1v infections, hospitalized in four tertiary centers in Brussels.
Results: We reported 215 children hospitalized with proven/probable H1N1 infection. Median age was 31 months. 47% had ≥ one co-morbidity. Febrile respiratory illness was the most common presentation. 36% presented initial gastrointestinal symptoms and 10% neurological manifestations. 35% had pneumonia. Compared to PCR, sensitivity of antigen and culture was low (53% and 59%, respectively). Only 23% of patients received oseltamivir. 21 (10%) children had to be admitted to ICU, of whom seven suffered from ARDS. Rate of co-morbidity tended to be higher among ICU than general wards patients (62%><45%,p=0.1). Fatality-rate was 5/215 (2%) and concerned only children suffering from chronic neurological disorders. Children > 2 years old showed a higher propensity to be admitted to ICU (16%><1%,p=0.002) and a higher mortality (4%>< 0%,p=0.06). Infants ≤ 3 months showed a particularly mild pattern of infection, with few respiratory and neurological complications.
Conclusion: Although H1N1 infections were globally self-limited, pediatric burden of disease was significant. Compared to other countries experiencing different health care systems, our Belgian cohort was younger and received less frequently antiviral therapy; disease course and mortality were however similar.
Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.



Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.


Save Settings