SURVEILLANCE OF VIRAL RESPIRATORY INFECTIONS IN THE EMERGENCY DEPARTMENT USING MICROARRAYS
ESPID Education. Kouni S. Jun 7, 2011; 7764
Dr. Sophia Kouni
Dr. Sophia Kouni

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SURVEILLANCE OF VIRAL RESPIRATORY INFECTIONS IN THE EMERGENCY DEPARTMENT USING MICROARRAYS

Kouni Sophia1, Karakitsos Petros2, Chranioti Aikaterini2, Theodoridou Maria1, Michos Athanasios1
1 First Department of Pediatrics, University of Athens, ‹‹Aghia Sofia›› Children’s Hospital
2 Department of Cytopathology, University of Athens, ‹‹Attikon›› University Hospital

Introduction: Impact of viral coinfections and recently discovered viruses on epidemiology of respiratory infections (RI) is still unclear.
Aim: To study the viruses that are involved in the etiology of RI we used microarrays that allow simultaneous detection of many viruses.
Methods: Rhinopharyngeal washes were taken from children (1 month-14 years) who presented in the emergency department from 1/2009 – 12/2010 with RI and treated as outpatients. Laboratory investigation was done for 17 viruses using a microarray platform.
Results:Out of 200 children, upper (URI) and lower (LRI) respiratory infections were diagnosed in 104 and 96 respectively. Viral coinfections were found in 20% of children. The most frequent combinations in URI were the PIV3 -Rhinovirus(9%), PIV- RSV(3%) and in LRI RSV-INFL(8%) and RSVA-RSVB(5%). PIV in URI and RSV in LRI were the prevalent viruses found in coinfections. The most common causes of single infection in URI were PIV3(22.7%), HRSVB(9%), Rhinovirus(9%), Enterovirus(7.5%), Infl(3%), Bocavirus(3%), Adenovirus(3%), HMPV(1.5%) and in children with LRI were RSVB(14.5%) Rhinovirus(11.2%), PIV3(11.2%), PIV4(11.2%), Influenza(8%), HRSVA(5%) and HMPV(3.2%). Respiratory distress was associated with Rhinovirus infection (P = 0.006), while no statistically significant relationship with severity was observed regarding viral coinfections (P = 0.667).
Conclusions: Viral coinfections and recently discovered viruses are involved in significant percentage of outpatient RI. Nevertheless, they are not associated with more serious clinical presentation as happens with rhinovirus infection that is related with respiratory distress. Viral microarrays method can probably help to reduce unnecessary hospitalizations and use of antibiotics in outpatient settings.


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