PERTUSSIS AFTER END OF A MASS VACCINATION PROJECT - END OF THE VACCINATION HONEY- MOON
ESPID Education. Trollfors B. Jun 7, 2011; 7767 Disclosure(s): No financial support from any source
Prof. Birger Trollfors
Prof. Birger Trollfors

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Abstract
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After 16 years of no vaccination against pertussis in Sweden, mass vaccination of infants and catch-up vaccination of children up to 10 years with a pertussis toxoid vaccine was performed in the Greater Gothenburg area 1995 - 1999. In 1999 56 % of all 10 year old children born in Greater Gothenburg had received 3 doses of the pertussis toxoid. No booster doses were given. This led to almost complete elimination of pertussis. The aim of the present study was to follow the incidence of pertussis after end of the mass vaccination project (1999 - 2009) as reflected by cultures and/or PCR. A reemergence was seen from the end of 1999 with a peak in 2004 followed by a decrease when booster doses to both 6 and 10 year old children were introduced in 2005 - 2006. From July 1, 1999 through December 31, 2009 a total of 1973 cases were diagnosed with culture or PCR. The disease was prevalent in all age
groups. The highest documented incidence was seen in infants. 450 patients with verified pertussis had received 3 doses of pertussis toxoid in the mass vaccination project and some other trials (comprising a total of 69,423 children). The mean time from the last dose to the laboratory verification of pertussis was 5 years in these 450 cases. In conclusion, pertussis is still not eliminated from the area. Booster doses are needed but the numbers and optimal timing are not known.
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