HIGH PREVALENCE OF LOW VITAMIN D IN HIV VERTICALLY INFECTED CHILDREN LIVING IN IRELAND
ESPID Education. Gavin P. Jun 7, 2011; 7790
Dr. Patrick Gavin
Dr. Patrick Gavin

This content is available to ESPID members only


Click here for more information or if you are considering becoming an ESPID member.

Abstract
Discussion Forum (0)
Rate & Comment (0)
Introduction
In addition to its key role in bone mineral metabolism, Vitamin D has important
immunomodulatory and antiinfective properties. Development of clinical rickets in
a 14 year old boy on HAART (FTC/TDF/EFV) prompted an audit of Vitamin D
status in our HIV infected cohort
Methods
Cross sectional study of vertically HIV infected children attending the National
Centre for Paediatric HIV Medicine in Ireland. Serum 1, 25 (OH) vitamin D levels
were defined as: deficient, <27.5nmol/L; low, 27.5nmol/L; and normal, >75nmol/L.
Parathormone (PTH) levels <65ng/mL were considered normal.
Results
Data were available on 66 children (35 male). Ethnicity: African, 52; Caucasian,
11; and mixed African-Caucasian, 3. Fifty one children were receiving HAART
(TDF, 20, EFV, 20 and 8/20 both TDF and EFV). Mean Vitamin D level was
43nmol/l (range, 7.8-112.2). Vitamin D levels were deficient, 15 (23%), low, 45
(68%) and normal, 6 (9%). Mean PTH level 64ng/ml (range, 15.8 – 804).
PTH levels were elevated in 10 (16%) of whom 7 (11%) were Vit D deficient with
elevated PTH levels, 3 with associated hypocalcaemia and hypophosphataemia.
Two received EFV; 1 TDF; 3 TDF/EFV and 1 was treatment naïve.
Urinary Calcium/Creatinine and Protein Creatinine ratios were normal in 42 of 43
(98%) children. One child had pre-existing HIV Nephropathy.
Conclusion
The majority (60/66, 91%) of our cohort of vertically infected children have low
vitamin D levels. PTH levels were elevated in 15%. In the absence of
demonstrable renal dysfunction, further study of additional mechanisms e.g.
inadequate intake, decreased absorption, drug effect, insufficient sunlight,
ethnicity is warrented.
Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.



Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.


Save Settings