ESPID Education. Prevaes S. Jun 7, 2011; 7794
Ms. S.M.P.J. Prevaes
Ms. S.M.P.J. Prevaes

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Pneumococcal conjugate vaccine (PCV-7) was implemented in the Dutch NIP in 2006. We studied the ongoing effect of PCV-7 introduction on nasopharyngeal pneumococcal carriage over time.

In follow-up of a randomized controlled trial (RCT) (NCT00189020), we performed two cross-sectional studies in 2009 and 2010 collecting nasopharyngeal swabs at 11 and 24 months of age from PCV-7 vaccinated children and from one of the parents of the latter group (n∼330 per group). Swabs were cultured for S. pneumoniae and serotyped by Quellung.

Results: In 11-month-olds PCV-7 carriage rates were 38%, 8% and 3% in 2005, 2009 and 2010, respectively, whereas in 24-month-olds vaccine serotype carriage was 36%, 3% and 3% (p<0.001 for all com
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