IMMUNOGLOBULIN DEFICIENCY IN CHILDREN WITH HIB VACCINE FAILURE
ESPID Education. Oeser C. Jun 7, 2011; 7955
Clarissa Oeser
Clarissa Oeser

This content is available to ESPID members only


Click here for more information or if you are considering becoming an ESPID member.

Abstract
Discussion Forum (0)
Rate & Comment (0)
Background:

Immunoglobulin (Ig) deficiency in children with Hib vaccine failure is well-described, but its clinical significance is unknown.

Aims:

To estimate the prevalence of Ig deficiency in children with Hib vaccine failure several years after infection and to determine their risk of recurrent infections

Methods

Children who developed invasive Hib disease after immunization with Hib conjugate vaccine from 1992 to 2006 were identified through national surveillance. Participation involved completion of a questionnaire and a blood sample from the child.

Results

A completed questionnaire and blood sample was provided by 170 children at a median of 4 years after infection, equivalent to 1035 child-years of follow-up. Ig deficiency was present in 11.2% and was associated with age <2 years at onset of Hib disease (63.2% vs. 39.7%, P=0.05) and receiving at least two antibiotic courses/year in early childhood (57.9% vs. 25.8%, P=0.004), but not with clinical presentation, severity of Hib infection or risk of other serious infections requiring hospitalization. In a logistic regression model, antibiotic use was independently associated with presence of an underlying medical condition (OR=7.3; 95% CI=2.3-22.7; P=0.001) and Ig deficiency (OR=5.4; 95%CI=1.8-16.0; P=0.003), while breastfeeding was protective (OR=0.30; 95%CI=0.14-0.65; P=0.002).

Conclusions

At 4 years after infection, the prevalence of Ig deficiency in children with Hib vaccine failure is half that reported in the first few months after Hib infection. Young children with Hib vaccine failure may have quantitative as well as qualitative antibody defects, which predisposes them to recurrent minor and occasionally serious infections, but improves with age.

Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.



Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.


Save Settings