TIMELINESS AND COMPLIANCE OF ROTAVIRUS VACCINATION IN AUSTRALIA
ESPID Education. GALIC M. Jun 7, 2011; 7958
Dr. MAJA GALIC
Dr. MAJA GALIC

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Abstract Title:
TIMELINESS AND COMPLIANCE OF ROTAVIRUS VACCINATION IN AUSTRALIA

Authors: M Galic1, A Pendleton1, S DiNatale1, C Keech1, Y Liu2
Affiliation:
1 GlaxoSmithKline (Aust) Pty Ltd, Victoria, Australia
3 GlaxoSmithKline Pte Ltd, Singapore

Background and aims
Two licensed rotavirus (RV) vaccines are funded under the Australian National Immunisation Program for all children born since May 2007. A two-dose vaccine, RIX4414, (RotarixTM, GlaxoSmithKline Biologicals) is funded in New South Wales (NSW). A three-dose vaccine, RV5 (RotaTeqTM, Merck and Co.) is funded in Queensland (QLD). We examined the compliance and timeliness of vaccination during 2007-2009.

Methods
Data from the Australian Childhood Immunisation Register (ACIR) was used to quantify the proportion of children completing the full vaccination series (CVS) regardless of age, mean age at each dose, and timeliness of receiving the two- dose or three-dose vaccine.

Results
Overall proportion of CVS was 80%. Mean (median) age for the two-dose series was 1.5 (2) and 3.8 (4) months, and 1.7 (2), 3.8 (4) and 6 (6) months for the three dose vaccine series.

Conclusions

Overall completion of the full series of RV vaccination is high, although vaccination rates fall as a series progresses. A higher compliance with a two-dose schedule and decreased timeliness with increasing doses is suggested. Further investigation is warranted.


Table 1: Percentage of children vaccinated, by median age and those who successfully completed the vaccination series regardless of age
Year Two-dose vaccine in NSW+ (RotarixTM) Three-dose vaccine in QLD+ (RotateqTM)
Total Number of children % of children receiving 1st dose by 2 months % of children receiving 2nd dose by 4 mo % of children complete vaccination at any age Total number of children % of children receiving 1st dose by 2 months % of children receiving second dose by 4 mo % of children receiving 3rd dose by 6 mo % of children fully complete vaccination at any age
07/08 98,357 79.8% 74.3%* 81% 97,847 75.2% 75.2% 68.9%* 78.1%
08/09 63,384 82.2% 77.9%^ 83.9% 62,388 84.5% 80.0% 74.0%^ 82.0%
+States investigated have similar modes of vaccine delivery (HCP, councils, others) and % indigenous populations
*p value <0.001 between last scheduled dose at cut off of median age of vaccination,
^p value <0.001 between last scheduled dose at cut off of median age of vaccination



Table 2: Timeliness of two-dose vaccine and three-dose vaccine in NSW and QLD

Rotavirus Vaccines Children vaccinated Dose 1 Dose 2 Dose 3
Two-dose vaccine in NSW (RotarixTM) Children born 2007-08 96%* 92%* N/A
Children born 2008-09 97%^ 93%^ N/A
Three-dose vaccine in QLD (RotateqTM) Children born 2007-08 98% 92%** 88%**
Children born 2008-09 98% 94%^^ 90%^^
*p value <0.001; ** p value <.001, ^p value <0.001; ^^ p value <.001 N/A not applicable
Note: Timeliness was defined as the proportion of all children who received vaccine prior to median age at administration: 2 month, 4 month and 6 month for 1st, 2nd, and 3rd doses respectively.




Key words: Rotavirus vaccine, compliance, timeliness, Rotarix, RotaTeq
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