IMPROVING PEDIATRIC TUBERCULOSIS DETECTION BY USING TRAINED AFRICAN GIANT POUCHED RATS: POTENTIAL TB DIAGNOSTIC SOLUTION FOR HIGH-BURDEN COUNTRIES
ESPID Education. Mgode G. May 30, 2018; 218765
Dr. Georgies Mgode
Dr. Georgies Mgode

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Understanding the olfactory based diagnostic method for pediatric tuberculosis in TB high burden countries
Background: Pediatric tuberculosis (TB) diagnosis is difficult in most resource constraint countries where sensitive diagnostic tools such a molecular techniques are not available or are inaccessible. In these settings up to 94 percent of children with TB are treated empirically especially in TB high burden countries. Sensitive and accurate diagnostic tests are much needed. The African giant pouched rats have been trained to detect pulmonary TB in human sputum samples. We evaluated the potential of using trained rats to detect pediatric TB and the TB yield compared to smear microscopy. Methods: Presumptive TB patients attending TB diagnosis in Tanzania were tested after diagnosis in the hospital. Rats re-tested the sputum and those suspected to have TB according to detection rats training were subjected for confirmation with approved method, concentrated smear-microscopy. TB yield of bacteriologically confirmed pediatric TB patients (≤5 year old) was compared with that of hospital smear microscopy. Results: Sputum samples from 982 children of 1–5 year old was tested by rats. Hospitals detected 34 bacteriologically positive children and rats detected additional 23 children yielding 57 bacteriologically TB-positive children. Rats increased pediatric TB detection by 68%. In the age group of 1-14 year old, hospitals detected 331 children with TB while rats detected additional 208 TB positive children who were initially missed by hospitals. Conclusion: Trained rats enhance pediatric TB detection and can recover missed positives. Further evaluation of pediatric TB detection by rats is needed to understand whether can detect TB in other sample types that can be easily obtained from children.
Mgode, Georgies F., et al. "Pediatric tuberculosis detection using trained African giant pouched rats." Pediatric research (2018).

Mgode, Georgies F., et al. "Mycobacterium tuberculosis volatiles for diagnosis of tuberculosis by Cricetomys rats." Tuberculosis 92.6 (2012): 535-542.

Mgode, Georgies F., et al. "Diagnosis of tuberculosis by trained African giant pouched rats and confounding impact of pathogens and microflora of the respiratory tract." Journal of clinical microbiology 50.2 (2012): 274-280.

Mgode, Georgies F., et al. "Ability of Cricetomys rats to detect Mycobacterium tuberculosis and discriminate it from other microorganisms." Tuberculosis 92.2 (2012): 182-186.
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