Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the netherlands
ESPID Education. Laksono B. May 9, 2019; 263135
Ms. Brigitta Marcella Laksono
Ms. Brigitta Marcella Laksono
Only ESPID Members have access to the ESPID 2019 content. To become a member click here
Abstract
Discussion Forum (0)
Rate & Comment (0)
Introduction
Measles causes a transient immune suppression, leading to increased susceptibility to opportunistic infections. Measles virus (MV) infection of immune cells is facilitated by the cellular receptor CD150. In experimentally infected non-human primates, MV infects and depletes CD150+ memory lymphocytes. Based on this finding, we postulated the ‘immune amnesia’ model to explain the mechanism of measles immune suppression. A measles outbreak in the Dutch Orthodox Protestant community in 2013 provided a unique opportunity to test this hypothesis in unvaccinated children.

Materials and methods
We performed an observational cohort study and enrolled more than 100 unvaccinated children before or early after MV infection. To determine levels of virus shedding and phenotypes of MV-infected cells (Cohort A), nose and throat swabs and blood samples were collected from patients with clinical signs of prodromal measles. To determine whether lymphocyte populations were depleted after measles (Cohort B), we collected paired blood samples from healthy children before and after measles.

Results
In Cohort A, we found that virus was shed more efficiently in the nose than in the throat. In the PBMC, we detected MV-infected memory CD4+ T, CD8+ T and B cells. In Cohort B, we found reduced frequencies of circulating memory B cells and increased frequencies of regulatory T and transitional B cells after measles.

Discussion and Conclusion
We show that measles viraemia in prodromal measles patients is largely mediated by MV-infected memory lymphocytes. Measles had a lasting impact on circulating lymphocyte subsets after recovery from the disease. These data support our immune amnesia hypothesis and offer an explanation for the previously observed long-term effects of measles on host resistance.
Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.



Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.


Save Settings